Nottingham Forest, led by new manager Vítor Pereira, will be favored to advance at the City Ground after their 3-0 first-leg victory at Fenerbahçe. The English club, struggling in 17th place in the Premier League, has not conceded a goal in its last three home European matches.
Stuttgart also has a commanding lead after beating Celtic 4-1 in front of a packed Celtic Park. Meanwhile, Genk leads Dinamo Zagreb 3-1, Bologna is 1-0 up against Brann, Celta holds a 2-1 advantage over PAOK, and Lille trails Red Star 1-0.